PARP2 Antibody

Product Specifications

Background

Parp2 is involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl) ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

NCBI Gene ID

11546

Swiss Prot

O88554

Accession Number

O88554

Host

Rabbit

Reactivity

Mouse

Immunogen

This PARP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-336 amino acids from the C-terminal region of human PARP2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

63 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Parp2

NCBI Official Name

Poly [ADP-ribose] polymerase 2

NCBI Organism

Mus musculus

Background Reference 01

Brunyanszki, A., et al. J. Invest. Dermatol. 130 (11) :2629-2637 (2010)

Background Reference 02

Toller, I.M., et al. Cancer Res. 70 (14) :5912-5922 (2010)

Background Reference 03

Nicolas, L., et al. Oncogene 29 (19) :2877-2883 (2010)

Background Reference 04

Li, X., et al. J. Neurochem. 113 (4) :1012-1022 (2010)

Other Product Names

Poly [ADP-ribose] polymerase 2, PARP-2, mPARP-2, ADP-ribosyltransferase diphtheria toxin-like 2, ARTD2, NAD (+) ADP-ribosyltransferase 2, ADPRT-2, Poly[ADP-ribose] synthase 2, pADPRT-2, Parp2, Adprt2, Adprtl2, Aspartl2