COX6B1 Antibody

Product Specifications

Background

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively.

NCBI Gene ID

1340

Swiss Prot

P14854

Accession Number

P14854

Host

Rabbit

Reactivity

Human

Immunogen

This COX6B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-86 amino acids from the C-terminal region of human COX6B1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

10 kDa

Fragment

Rabbit Ig

Symbol

COX6B1

NCBI Official Name

Cytochrome c oxidase subunit 6B1

NCBI Organism

Homo sapiens

Background Reference 01

Lazarou, M., et al. FEBS J. 276 (22) :6701-6713 (2009)

Background Reference 02

Massa, V., et al. Am. J. Hum. Genet. 82 (6) :1281-1289 (2008)

Background Reference 03

Sirchia, R., et al. Biol. Chem. 388 (5) :457-465 (2007)

Background Reference 04

Schmidt, T.R., et al. Gene 286 (1) :13-19 (2002)

Other Product Names

Cytochrome c oxidase subunit 6B1, Cytochrome c oxidase subunit VIb isoform 1, COX VIb-1, COX6B1, COX6B

Tested Applications

WB, IHC-P

Protein ID

117115

Physical Properties

Liquid

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