DVL1 Antibody

Product Specifications

Background

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.

NCBI Gene ID

1855

Swiss Prot

O14640

Accession Number

O14640

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This DVL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-470 amino acids from the Central region of human DVL1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

75 kDa

Fragment

Rabbit Ig

Symbol

DVL1

NCBI Official Name

Segment polarity protein dishevelled homolog DVL-1

NCBI Organism

Homo sapiens

Background Reference 01

Metcalfe, C., et al. J. Cell. Sci. 123 (PT 9), 1588-1599 (2010) :

Background Reference 02

Hu, T., et al. J. Biol. Chem. 285 (18) :13561-13568 (2010)

Background Reference 03

Varelas, X., et al. Dev. Cell 18 (4) :579-591 (2010)

Background Reference 04

Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

Other Product Names

Segment polarity protein dishevelled homolog DVL-1, Dishevelled-1, DSH homolog 1, DVL1

Tested Applications

WB, IHC-P, IF

Physical Properties

Liquid

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