GBA3 Antibody

Product Specifications

Background

GBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides (de Graaf et al., 2001 [PubMed 11389701]) . GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (Hayashi et al., 2007 [PubMed 17595169]) .

NCBI Gene ID

57733

Swiss Prot

Q9H227

Accession Number

Q9H227

Host

Rabbit

Reactivity

Human

Immunogen

This GBA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the C-terminal region of human GBA3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

54 kDa

Fragment

Rabbit Ig

Symbol

GBA3

NCBI Official Name

Cytosolic beta-glucosidase

NCBI Organism

Homo sapiens

Background Reference 01

Dekker, N., et al. Blood Cells Mol. Dis. (2010) In press :

Background Reference 02

Noguchi, J., et al. Biochem. Biophys. Res. Commun. 374 (3) :549-552 (2008)

Background Reference 03

Hayashi, Y., et al. J. Biol. Chem. 282 (42) :30889-30900 (2007)

Background Reference 04

Tribolo, S., et al. J. Mol. Biol. 370 (5) :964-975 (2007)

Other Product Names

Cytosolic beta-glucosidase, Cytosolic beta-glucosidase-like protein 1, GBA3, CBG, CBGL1

Tested Applications

WB, IHC-P

Protein ID

77416427

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

sc-39346-V 200 µL

CCL27 shRNA (h) Lentiviral Particles

Ask

View Details

SN0020-01 50 Tests

Nuclear Extraction Kit

Ask

View Details

SN0020-02 100 Tests

Nuclear Extraction Kit

Ask

View Details

HY-RS10281 1 Set

PDLIM3 Human Pre-designed siRNA Set A

Ask

View Details

GTR15215517 1 Vial

Lentiviral mouse Pwp2 shRNA (UAS) - Lentiviral mouse Pwp2 shRNA (UAS, GFP) (100)

Ask

View Details

427937-01 50 mg

(3R,4R,5R) -3,4-Dihydroxy-5-[ (methylsulfonyl) oxy]-1-cyclohexene-1-carboxylic Acid Ethyl Ester

Ask

View Details