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F2RL2 Antibody

Product Specifications

Background

Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.

NCBI Gene ID

2151

Swiss Prot

O00254

Accession Number

O00254

Host

Rabbit

Reactivity

Human

Immunogen

This F2RL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human F2RL2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=56-323

Calculated Molecular Weight

43 kDa

Fragment

Rabbit Ig

Symbol

F2RL2

NCBI Official Name

Proteinase-activated receptor 3

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 02

Popovic, M., et al. J. Thromb. Thrombolysis 30 (2) :164-171 (2010)

Background Reference 03

Van Laer, L., et al. Eur. J. Hum. Genet. 18 (6) :685-693 (2010)

Background Reference 04

Wysoczynski, M., et al. Mol. Cancer Res. 8 (5) :677-690 (2010)

Other Product Names

Proteinase-activated receptor 3, PAR-3, Coagulation factor II receptor-like 2, Thrombin receptor-like 2, F2RL2, PAR3

Tested Applications

WB, IHC-P

Physical Properties

Liquid

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