SMPD1 Antibody
Product Specifications
Background
The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB) . Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq].
NCBI Gene ID
6609
Swiss Prot
P17405
Accession Number
P17405
Host
Rabbit
Reactivity
Human
Immunogen
This SMPD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the C-terminal region of human SMPD1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=56-289
Calculated Molecular Weight
70 kDa
Fragment
Rabbit Ig
Symbol
SMPD1
NCBI Official Name
Sphingomyelin phosphodiesterase
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010) Desnick, J.P., et al. Mol. Med. 16 (7-8), 316-321 (2010) Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009) Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007) Sleat, D.E., et al. Mol. Cell Proteomics 5 (4) :686-701 (2006)
Other Product Names
Sphingomyelin phosphodiesterase, Acid sphingomyelinase, aSMase, SMPD1, ASM
Tested Applications
WB, IHC-P, Flow
Protein ID
224471897
Physical Properties
Liquid
Curated Selection
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