SMPD1 Antibody

Product Specifications

Background

The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB) . Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq].

NCBI Gene ID

6609

Swiss Prot

P17405

Accession Number

P17405

Host

Rabbit

Reactivity

Human

Immunogen

This SMPD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the C-terminal region of human SMPD1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

70 kDa

Fragment

Rabbit Ig

Symbol

SMPD1

NCBI Official Name

Sphingomyelin phosphodiesterase

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010) Desnick, J.P., et al. Mol. Med. 16 (7-8), 316-321 (2010) Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009) Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007) Sleat, D.E., et al. Mol. Cell Proteomics 5 (4) :686-701 (2006)