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CHRNA10 Antibody

Product Specifications

Background

CHRNA10 is an ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

NCBI Gene ID

57053

Swiss Prot

Q9GZZ6

Accession Number

Q9GZZ6

Host

Rabbit

Reactivity

Human

Immunogen

This CHRNA10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179-206 amino acids from the Central region of human CHRNA10.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=56-266

Calculated Molecular Weight

50 kDa

Fragment

Rabbit Ig

Symbol

CHRNA10

NCBI Official Name

Neuronal acetylcholine receptor subunit alpha-10

NCBI Organism

Homo sapiens

Background Reference 01

Saccone, N.L., et al. Genes Brain Behav. 9 (7) :741-750 (2010)

Background Reference 02

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 03

Rigbi, A., et al. Pharmacogenomics J. (2010) In press :

Background Reference 04

Need, A.C., et al. Eur. J. Hum. Genet. 17 (7) :946-957 (2009)

Other Product Names

Neuronal acetylcholine receptor subunit alpha-10, Nicotinic acetylcholine receptor subunit alpha-10, NACHR alpha-10, CHRNA10, NACHRA10

Tested Applications

WB, IHC-P

Protein ID

14916526

Physical Properties

Liquid

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