MDK Antibody

Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angiogenesis (summary by Reynolds et al., 2004 [PubMed 15197188]) .

This MDK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-143 amino acids from the C-terminal region of human MDK.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Ferreira, R.C., et al. Nat. Genet. 42 (9) :777-780 (2010) Kerzerho, J., et al. J. Immunol. 185 (1) :418-423 (2010) Yao, X., et al. Acta Pharmacol. Sin. 31 (5) :629-637 (2010) Zhang, Z.H., et al. Cell Prolif. 43 (2) :184-194 (2010) Rice, G.E., et al. J. Exp. Clin. Cancer Res. 29, 62 (2010) :

Midkine, MK, Amphiregulin-associated protein, ARAP, Midgestation and kidney protein, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein, MDK, MK1, NEGF2