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PCAF Antibody

Product Specifications

Background

CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.

NCBI Gene ID

8850

Swiss Prot

Q92831

Accession Number

Q92831

Host

Rabbit

Reactivity

Human

Immunogen

This PCAF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-283 amino acids from the N-terminal region of human PCAF.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=56-212

Calculated Molecular Weight

93 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

KAT2B

NCBI Official Name

Histone acetyltransferase KAT2B

NCBI Organism

Homo sapiens

Background Reference 01

Perez, R.E., et al. J. Cell. Physiol. 225 (2) :394-405 (2010)

Background Reference 02

Mooney, S.M., et al. J. Biol. Chem. 285 (40) :30443-30452 (2010)

Background Reference 03

Aoyama, T., et al. J. Biol. Chem. 285 (39) :29842-29850 (2010)

Background Reference 04

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Other Product Names

Histone acetyltransferase KAT2B, Histone acetyltransferase PCAF, Histone acetylase PCAF, Lysine acetyltransferase 2B, P300/CBP-associated factor, P/CAF, KAT2B, PCAF

Tested Applications

WB

Protein ID

83287776

Physical Properties

Liquid

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