FOXN1 Antibody

Product Specifications

Background

Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq].

NCBI Gene ID

8456

Swiss Prot

O15353

Accession Number

O15353

Host

Rabbit

Reactivity

Human

Immunogen

This FOXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-378 amino acids from the Central region of human FOXN1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

69 kDa

Fragment

Rabbit Ig

Symbol

FOXN1

NCBI Official Name

Forkhead box protein N1

NCBI Organism

Homo sapiens

Background Reference 01

Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

Background Reference 02

Mandinova, A., et al. J. Clin. Invest. 119 (10) :3127-3137 (2009)

Background Reference 03

Pignata, C., et al. Adv. Exp. Med. Biol. 665, 195-206 (2009) :

Background Reference 04

Weiner, L., et al. Cell 130 (5) :932-942 (2007)

Other Product Names

Forkhead box protein N1, Winged-helix transcription factor nude, FOXN1, RONU, WHN

Tested Applications

WB, Flow

Physical Properties

Liquid

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