GSR Antibody
Product Specifications
Background
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
NCBI Gene ID
2936
Swiss Prot
P00390
Accession Number
P00390
Host
Rabbit
Reactivity
Human
Immunogen
This GSR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-408 amino acids from the C-terminal region of human GSR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
56 kDa
Fragment
Rabbit Ig
Symbol
GSR
NCBI Official Name
Glutathione reductase, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Satoh, N., et al. Biochem. Genet. 48 (9-10), 816-821 (2010) :
Background Reference 02
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 03
Wang, Y., et al. J. Hum. Genet. 55 (8) :490-494 (2010)
Background Reference 04
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Other Product Names
Glutathione reductase, mitochondrial, GR, GRase, GSR, GLUR, GRD1
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
14916998
Physical Properties
Liquid
Curated Selection
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