XCR1 Antibody

Product Specifications

Background

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

NCBI Gene ID

2829

Swiss Prot

P46094

Accession Number

P46094

Host

Rabbit

Reactivity

Human

Immunogen

This XCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-333 amino acids from the C-terminal region of human XCR1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

39 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

XCR1

NCBI Official Name

Chemokine XC receptor 1

NCBI Organism

Homo sapiens

Background Reference 01

Yamazaki, C., et al. Biochem. Biophys. Res. Commun. 397 (4) :756-761 (2010)

Background Reference 02

Crozat, K., et al. J. Exp. Med. 207 (6) :1283-1292 (2010)

Background Reference 03

Bachem, A., et al. J. Exp. Med. 207 (6) :1273-1281 (2010)

Background Reference 04

Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

Other Product Names

Chemokine XC receptor 1, G-protein coupled receptor 5, Lymphotactin receptor, XC chemokine receptor 1, XCR1, CCXCR1, GPR5

Tested Applications

Protein ID

1170008

Physical Properties

Liquid

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