XRCC5 Antibody
Product Specifications
Background
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V (D) J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V (D) J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
NCBI Gene ID
7520
Swiss Prot
P13010
Accession Number
P13010
Host
Rabbit
Reactivity
Human
Immunogen
This XRCC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 424-450 amino acids from the Central region of human XRCC5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=56-143
Calculated Molecular Weight
83 kDa
Fragment
Rabbit Ig
Symbol
XRCC5
NCBI Official Name
X-ray repair cross-complementing protein 5
NCBI Organism
Homo sapiens
Background Reference 01
Gomes, B.C., et al. Oncol. Rep. 24 (4) :1079-1085 (2010)
Background Reference 02
Liu, Y., et al. Carcinogenesis 31 (10) :1762-1769 (2010)
Background Reference 03
Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :
Background Reference 04
Briggs, F.B., et al. Am. J. Epidemiol. 172 (2) :217-224 (2010)
Other Product Names
X-ray repair cross-complementing protein 5, 364-, 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 80 kDa subunit, CTC box-binding factor 85 kDa subunit, CTC85, CTCBF, DNA repair protein XRCC5, Ku80, Ku86, Lupus Ku autoantigen protein p86, Nuclear factor IV, Thyroid-lupus autoantigen, TLAA, X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining), XRCC5, G22P2
Tested Applications
WB, IF, Flow
Protein ID
125731
Physical Properties
Liquid
Curated Selection
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