LGALS3 Antibody

Product Specifications

Background

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.

NCBI Gene ID

3958

Swiss Prot

P17931

Accession Number

P17931

Host

Rabbit

Reactivity

Human

Immunogen

This LGALS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the C-terminal region of human LGALS3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

26 kDa

Fragment

Rabbit Ig

Symbol

LGALS3

NCBI Official Name

Galectin-3

NCBI Organism

Homo sapiens

Background Reference 01

Salomonsson, E., et al. J. Biol. Chem. 285 (45) :35079-35091 (2010)

Background Reference 02

Debierre-Grockiego, F., et al. J. Biol. Chem. 285 (43) :32744-32750 (2010)

Background Reference 03

Zhou, J.Y., et al. J. Proteome Res. 9 (10) :5133-5141 (2010)

Background Reference 04

Markowska, A.I., et al. J. Exp. Med. 207 (9) :1981-1993 (2010)

Other Product Names

Galectin-3, Gal-3, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Galactose-specific lectin 3, Galactoside-binding protein, GALBP, IgE-binding protein, L-31, Laminin-binding protein, Lectin L-29, Mac-2 antigen, LGALS3, MAC2