IRF9 Antibody

Product Specifications

Background

IRF9 is a transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

NCBI Gene ID

10379

Swiss Prot

Q00978

Accession Number

Q00978

Host

Rabbit

Reactivity

Mouse

Immunogen

This IRF9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-104 amino acids from the N-terminal region of human IRF9.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Inflammasomes

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

44 kDa

Fragment

Rabbit Ig

Symbol

IRF9

NCBI Official Name

Interferon regulatory factor 9

NCBI Organism

Homo sapiens

Background Reference 01

Maiwald, T., et al. FEBS J. 277 (22) :4741-4754 (2010)

Background Reference 02

Schuurhof, A., et al. Pediatr. Pulmonol. 45 (6) :608-613 (2010)

Background Reference 03

Watanabe, T., et al. J. Clin. Invest. 120 (5) :1645-1662 (2010)

Background Reference 04

Mosbruger, T.L., et al. J. Infect. Dis. 201 (9) :1371-1380 (2010)

Other Product Names

Interferon regulatory factor 9, IRF-9, IFN-alpha-responsive transcription factor subunit, ISGF3 p48 subunit, Interferon-stimulated gene factor 3 gamma, ISGF-3 gamma, Transcriptional regulator ISGF3 subunit gamma, IRF9, ISGF3G