IRF9 Antibody
Product Specifications
Background
IRF9 is a transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
NCBI Gene ID
10379
Swiss Prot
Q00978
Accession Number
Q00978
Host
Rabbit
Reactivity
Mouse
Immunogen
This IRF9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-104 amino acids from the N-terminal region of human IRF9.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Inflammasomes
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=56-092
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Symbol
IRF9
NCBI Official Name
Interferon regulatory factor 9
NCBI Organism
Homo sapiens
Background Reference 01
Maiwald, T., et al. FEBS J. 277 (22) :4741-4754 (2010)
Background Reference 02
Schuurhof, A., et al. Pediatr. Pulmonol. 45 (6) :608-613 (2010)
Background Reference 03
Watanabe, T., et al. J. Clin. Invest. 120 (5) :1645-1662 (2010)
Background Reference 04
Mosbruger, T.L., et al. J. Infect. Dis. 201 (9) :1371-1380 (2010)
Other Product Names
Interferon regulatory factor 9, IRF-9, IFN-alpha-responsive transcription factor subunit, ISGF3 p48 subunit, Interferon-stimulated gene factor 3 gamma, ISGF-3 gamma, Transcriptional regulator ISGF3 subunit gamma, IRF9, ISGF3G
Tested Applications
WB, IHC-P, IF
Protein ID
266392
Physical Properties
Liquid
Curated Selection
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