CLCN7 Antibody

Product Specifications

Background

The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood.

NCBI Gene ID

1186

Swiss Prot

P51798

Accession Number

P51798

Host

Rabbit

Reactivity

Human

Immunogen

This CLCN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-720 amino acids from the C-terminal region of human CLCN7.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

89 kDa

Fragment

Rabbit Ig

Symbol

CLCN7

NCBI Official Name

H (+) /Cl (-) exchange transporter 7

NCBI Organism

Homo sapiens

Background Reference 01

Furthner, D., et al. Klin Padiatr 222 (3) :180-183 (2010)

Background Reference 02

Phadke, S.R., et al. Indian J. Med. Res. 131, 508-514 (2010) :

Background Reference 03

Pangrazio, A., et al. Hum. Mutat. 31 (1), E1071-E1080 (2010) :

Background Reference 04

Kajiya, H., et al. Pflugers Arch. 458 (6) :1049-1059 (2009)

Other Product Names

H (+) /Cl (-) exchange transporter 7, Chloride channel 7 alpha subunit, Chloride channel protein 7, ClC-7, CLCN7

Tested Applications

WB, IHC-P, IF

Protein ID

12644301

Physical Properties

Liquid

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