TGFBR2 Antibody
Product Specifications
Background
This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
NCBI Gene ID
7048
Swiss Prot
P37173
Accession Number
P37173
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This TGFBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-40 amino acids from the N-terminal region of human TGFBR2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=56-081
Calculated Molecular Weight
65 kDa
Fragment
Rabbit Ig
Symbol
TGFBR2
NCBI Official Name
TGF-beta receptor type-2
NCBI Organism
Homo sapiens
Background Reference 01
Inamoto, S., et al. Cardiovasc. Res. 88 (3) :520-529 (2010)
Background Reference 02
Bianchini, G., et al. J. Clin. Oncol. 28 (28) :4316-4323 (2010)
Background Reference 03
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 04
Kim, J.N., et al. Toxicology 275 (1-3), 29-35 (2010) :
Other Product Names
TGF-beta receptor type-2, TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II, TGFBR2
Tested Applications
WB, IHC-P, IF
Protein ID
116242818
Physical Properties
Liquid
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