PURA Antibody

Product Specifications

Background

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.

NCBI Gene ID

5813

Swiss Prot

Q00577

Accession Number

Q00577

Host

Rabbit

Reactivity

Human

Immunogen

This PURA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 259-287 amino acids from the C-terminal region of human PURA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

35 kDa

Fragment

Rabbit Ig

Symbol

PURA

NCBI Official Name

Transcriptional activator protein Pur-alpha

NCBI Organism

Homo sapiens

Background Reference 01

Inoue, T., et al. Prostate 69 (8) :861-873 (2009)

Background Reference 02

Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259 (3) :151-163 (2009)

Background Reference 03

Kaminski, R., et al. Cancer Biol. Ther. 7 (12) :1926-1935 (2008)

Background Reference 04

Darbinian, N., et al. J. Alzheimers Dis. 15 (1) :71-82 (2008)

Other Product Names

Transcriptional activator protein Pur-alpha, Purine-rich single-stranded DNA-binding protein alpha, PURA, PUR1

Tested Applications

WB, IHC-P

Protein ID

1346918

Physical Properties

Liquid

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