ITGA8 Antibody
Product Specifications
Background
Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
NCBI Gene ID
8516
Swiss Prot
P53708
Accession Number
P53708
Host
Rabbit
Reactivity
Human
Immunogen
This ITGA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1025-1053 amino acids from the C-terminal region of human ITGA8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
117 kDa
Fragment
Rabbit Ig
Symbol
ITGA8
NCBI Official Name
Integrin alpha-8
NCBI Organism
Homo sapiens
Background Reference 01
Benoit, Y.D., et al. Biochem. Biophys. Res. Commun. 399 (3) :434-439 (2010)
Background Reference 02
Simon-Sanchez, J., et al. Nat. Genet. 41 (12) :1308-1312 (2009)
Background Reference 03
Benoit, Y.D., et al. Biol. Cell 101 (12) :695-708 (2009)
Background Reference 04
Sato, Y., et al. J. Biol. Chem. 284 (21) :14524-14536 (2009)
Other Product Names
Integrin alpha-8, Integrin alpha-8 heavy chain, Integrin alpha-8 light chain, ITGA8
Tested Applications
WB, IHC-P
Protein ID
311033437
Physical Properties
Liquid
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
AE33662HU-01 48 Tests
Human Microfibril-associated glycoprotein 3 (MFAP3) ELISA Kit
Ask
View Details AE33662HU-02 96 Tests
Human Microfibril-associated glycoprotein 3 (MFAP3) ELISA Kit
Ask
View Details