EDN1 Antibody

Product Specifications

Background

The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

1906

Swiss Prot

P05305

Accession Number

P05305

Host

Rabbit

Reactivity

Human

Immunogen

This EDN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-138 amino acids from the Central region of human EDN1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

24 kDa

Fragment

Rabbit Ig

Symbol

EDN1

NCBI Official Name

Endothelin-1

NCBI Organism

Homo sapiens

Background Reference 01

Gonsalves, C., et al. J. Immunol. 185 (10) :6253-6264 (2010)

Background Reference 02

Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :

Background Reference 03

Feng, J., et al. Circulation 122 (11 SUPPL), S150-S155 (2010) :

Background Reference 04

Nikopensius, T., et al. Birth Defects Res. PartClin. Mol. Teratol. 88 (9) :748-756 (2010)

Other Product Names

Endothelin-1, Preproendothelin-1, PPET1, Endothelin-1, ET-1, Big endothelin-1, EDN1

Tested Applications

WB, IHC-P, IF, Flow

Protein ID

119610

Physical Properties

Liquid

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