AHCY Antibody

Product Specifications

Background

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy) . Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

191

Swiss Prot

P23526

Accession Number

P23526

Host

Rabbit

Reactivity

Mouse

Immunogen

This AHCY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-110 amino acids from the N-terminal region of human AHCY.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Pig

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

48 kDa

Fragment

Rabbit Ig

Symbol

AHCY

NCBI Official Name

Adenosylhomocysteinase

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 02

Gass, N., et al.Affect Disord 126 (1-2), 134-139 (2010) :

Background Reference 03

Giusti, B., et al. Thromb. Haemost. 104 (2) :231-242 (2010)

Background Reference 04

Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19 (7) :1812-1821 (2010)

Other Product Names

Adenosylhomocysteinase, AdoHcyase, S-adenosyl-L-homocysteine hydrolase, AHCY, SAHH

Tested Applications

WB, IHC-P, Flow

Protein ID

20141702

Physical Properties

Liquid

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