ETFA Antibody

ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene.

This ETFA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276-304 amino acids from the C-terminal region of human ETFA.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Ohkuma, A., et al. Muscle Nerve 39 (3) :333-342 (2009) Chiong, M.A., et al. Mol. Genet. Metab. 92 (1-2), 109-114 (2007) Olsen, J.V., et al. Cell 127 (3) :635-648 (2006) Olsen, J.V., et al. Cell 127 (3) :635-648 (2006) Schiff, M., et al. Mol. Genet. Metab. 88 (2) :153-158 (2006)