HDAC11 Antibody
Product Specifications
Background
HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
NCBI Gene ID
79885
Swiss Prot
Q96DB2
Accession Number
Q96DB2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This HDAC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 313-345 amino acids from the C-terminal region of human HDAC11.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=55-646
Calculated Molecular Weight
39 kDa
Fragment
Rabbit Ig
Symbol
HDAC11
NCBI Official Name
Histone deacetylase 11
NCBI Organism
Homo sapiens
Background Reference 01
Keedy, K.S. et al.Virol. May; 83 (10) : 4749?756 (2009) .
Background Reference 02
Voelter-Mahlknecht S, et al., IntMol Med. 2005 Oct;16 (4) :589-98.
Background Reference 03
Bradbury CA, et al., Leukemia. 2005 Oct;19 (10) :1751-9.
Background Reference 04
Gregoretti IV, et al., Mol Biol. 2004 Apr 16;338 (1) :17-31.
Other Product Names
Histone deacetylase 11, HD11, HDAC11
Tested Applications
WB, IHC-P
Protein ID
26394832
Physical Properties
Liquid
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