GGCX Antibody

Product Specifications

Background

This gene encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

2677

Swiss Prot

P38435

Accession Number

P38435

Host

Rabbit

Reactivity

Human

Immunogen

This GGCX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 548-578 amino acids from the Central region of human GGCX.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

88 kDa

Fragment

Rabbit Ig

Symbol

GGCX

NCBI Official Name

Vitamin K-dependent gamma-carboxylase

NCBI Organism

Homo sapiens

Background Reference 01

Higgins-Gruber, S.L., et al. J. Biol. Chem. 285 (41) :31502-31508 (2010)

Background Reference 02

King, C.R., et al. Thromb. Haemost. 104 (4) :750-754 (2010)

Background Reference 03

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 04

Ikejiri, M., et al. Int. J. Hematol. 92 (2) :302-305 (2010)

Other Product Names

Vitamin K-dependent gamma-carboxylase, Gamma-glutamyl carboxylase, Peptidyl-glutamate 4-carboxylase, Vitamin K gamma glutamyl carboxylase, GGCX, GC

Tested Applications

WB, IHC-P

Protein ID

84028279

Physical Properties

Liquid

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