IRF1 Antibody

Product Specifications

Background

IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.

NCBI Gene ID

3659

Swiss Prot

P10914

Accession Number

P10914

Host

Rabbit

Reactivity

Human

Immunogen

This IRF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-286 amino acids from the C-terminal region of human IRF1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other, Inflammasomes

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

37 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

IRF1

NCBI Official Name

Interferon regulatory factor 1

NCBI Organism

Homo sapiens

Background Reference 01

Silva, L.K., et al. Eur. J. Hum. Genet. 18 (11) :1221-1227 (2010)

Background Reference 02

Matsuzaki, S., et al. J. Immunol. 185 (8) :4863-4872 (2010)

Background Reference 03

Antonios, D., et al. J. Immunol. 185 (1) :89-98 (2010)

Background Reference 04

Lou, Y.J., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27 (3) :255-258 (2010)

Other Product Names

Interferon regulatory factor 1, IRF-1, IRF1

Tested Applications

Protein ID

20178295

Physical Properties

Liquid

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