HNF1B Antibody

Product Specifications

Background

This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

6928

Swiss Prot

P35680

Accession Number

P35680

Host

Rabbit

Reactivity

Human

Immunogen

This HNF1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 498-529 amino acids from the C-terminal region of human HNF1B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

61 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

HNF1B

NCBI Official Name

Hepatocyte nuclear factor 1-beta

NCBI Organism

Homo sapiens

Background Reference 01

Jablonski, K.A., et al. Diabetes 59 (10) :2672-2681 (2010)

Background Reference 02

Oram, R.A., et al. Am. J. Obstet. Gynecol. 203 (4), 364 (2010) :

Background Reference 03

Takata, R., et al. Nat. Genet. 42 (9) :751-754 (2010)

Background Reference 04

Liu, H., et al. Prostate (2010) In press :

Other Product Names

Hepatocyte nuclear factor 1-beta, HNF-1-beta, HNF-1B, Homeoprotein LFB3, Transcription factor 2, TCF-2, Variant hepatic nuclear factor 1, vHNF1, HNF1B, TCF2