CAF-1 Antibody

Product Specifications

Background

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.

NCBI Gene ID

29883

Swiss Prot

Q9UIV1

Accession Number

Q9UIV1

Host

Rabbit

Reactivity

Human

Immunogen

This CAF-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-61 amino acids from the N-terminal region of human CAF-1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Zebrafish, Mouse, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

33 kDa

Fragment

Rabbit Ig

Symbol

CNOT7

NCBI Official Name

CCR4-NOT transcription complex subunit 7

NCBI Organism

Homo sapiens

Background Reference 01

Lau, N.C., et al. Biochem. J. 422 (3) :443-453 (2009)

Background Reference 02

Aslam, A., et al. Mol. Biol. Cell 20 (17) :3840-3850 (2009)

Background Reference 03

Miyasaka, T., et al. Cancer Sci. 99 (4) :755-761 (2008)

Background Reference 04

Nishida, K., et al. Acta Crystallogr. Sect.Struct. Biol. Cryst. Commun. 63 (PT 12), 1061-1063 (2007) :

Other Product Names

CCR4-NOT transcription complex subunit 7, BTG1-binding factor 1, CCR4-associated factor 1, CAF-1, Caf1a, CNOT7, CAF1

Tested Applications

WB, IHC-P, IF

Protein ID

41713629

Physical Properties

Liquid

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