Vimentin Antibody
Product Specifications
Background
Vimentin is the major protein subunit of the 10nm or intermediate filaments (IFs) found in many kinds of mesenchymal and epithelial cells as well as developing neuronal and astrocytic precursor cells in the CNS. Vimentin is thought to be critically involved in lymphocyte adhesion and transmigration (Nieminen M et al. 2006) . Copolymers are frequently formed between vimentin and other IFs, such as GFAP (in many kinds of astrocytes), desmin (in muscle cells) and neurofilament proteins (in developing neurons) . Antibodies to vimentin are useful in studies of stem cells and generally to reveal the filamentous cytoskeleton. Recent studies suggest that vimentin affects prostate cancer cells motility and invasiveness (Zhao et al. 2008) .
NCBI Gene ID
7431
Swiss Prot
P08670
Accession Number
P08670
Host
Chicken
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant human Vimentin purified from E. coli.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell, Cancer
Purification
Total IgY fraction
Concentration
Batch dependent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Vimentin antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Calculated Molecular Weight
50
Specificity
Specific for the ~50kDa Vimentin protein.
Symbol
VIM
NCBI Official Name
Vimentin
NCBI Organism
Homo sapiens
Background Reference 01
Nieminen M, Henttinen T, Merinen M, Marttila-Ichihara F, Eriksson JE, Jalkanen S (2006) Vimentin function in lymphocyte adhesion and transcellular migration. Nat Cell Biol 8 (2) :156-62.
Background Reference 02
Zhao Y, Yan Q, Long X, Chen X, Wang Y (2008) Vimentin affects the mobility and invasiveness of prostate cancer cells. Cell Biochem Funct. May 8
Tested Applications
WB, IHC
Protein ID
55977767
Physical Properties
Liquid
Curated Selection
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