Neurofilament NF-L Antibody [DA2]
Product Specifications
Background
Neurofilaments are the 10nm or intermediate filament proteins specifically in neurons, and are composed predominantly of three major proteins called NF- NF-M and NF-H. NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68 kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. Mutations in the protein region of the human NF-L gene cause some forms of Charcot-Marie-Tooth disease.
NCBI Gene ID
4747
Swiss Prot
P07196
Accession Number
P07196
Host
Mouse
Reactivity
Human, Mouse, Rat, Bovine, Chicken
Immunogen
Preparation of porcine intermediate filaments.
Clonality
Monoclonal
Clone
DA2
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Total IgG fraction
Concentration
Batch dependent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Neurofilament NF-L antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Calculated Molecular Weight
68
Fragment
IgG1
Specificity
Specific for the ~68k Neurofilament L protein.
Symbol
NEFL
NCBI Official Name
Neurofilament, light polypeptide
NCBI Organism
Homo sapiens
Background Reference 01
Harris, J., Ayyub, C. and Shaw G. (1991) A molecular dissection of the carboxyterminal tails of the major neurofilament subunits NF-M and NF-H. J Neurosci Res 30:47-62.
Background Reference 02
Mersiyanova IV, Perepelov AV, Polyakov AV, Sitnikov VF, Dadali EL, Oparin RB, Petrin AN and Evgrafov OV. (2000) A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene. Am. J. Hum. Genet. 67:37-46.
Tested Applications
WB, IHC
Protein ID
62511894
Physical Properties
Liquid
Curated Selection
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