Parkin (phospho Ser378) Antibody
Product Specifications
Background
Parkin is an E3 ligase in the ubiquitin-proteasome system. Hereditary Parkinson’s disease is most commonly caused by mutations in the parkin gene and is characterized by the progressive loss of dopaminergic neurons and the presence of Lewy bodies in the substania nigra (Jenner aet al.,1992) . Recent evidence suggests that phosphorylation of parkin at Ser378 may have an important regulatory role on its E3 ubiquitin ligase activity (Yamamoto et al., 2005) .
NCBI Gene ID
5071
Swiss Prot
O60260
Accession Number
O60260
Host
Rabbit
Reactivity
Human
Immunogen
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser378 of human parkin.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Affinity Purified
Concentration
Batch dependent
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Parkin antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Calculated Molecular Weight
52
Applications Notes
The antibody has been directly tested for reactivity in Western blots with human tissue.
Symbol
PARK2
NCBI Official Name
Parkin RBR E3 ubiquitin protein ligase
NCBI Organism
Homo sapiens
Background Reference 01
Jenner P, Dexter DT, Sian J, Schapira AH, Marsden CD (1992) Oxidative stress as a cause of nigral cell death in Parkinson’s disease and incidental Lewy body disease. Ann Neurol. 32 Suppl: S82-7.
Background Reference 02
Yamamoto A, Friedlein A, Imai Y, Takahashi R, Kahle PJ, Haass C (2005) Parkin phosphorylation and modulation of its E# ubiquitin ligase activity. J Biol chem. 280 (5) :3390-9
Tested Applications
WB
Protein ID
116242725
Physical Properties
Liquid
Frequently Asked Questions
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