Rabphilin (phospho Ser234) Antibody
Product Specifications
Background
Rabphilin-3A is a peripheral membrane protein that binds Ca2+ and phospholipids and is attached to synaptic vesicle membranes (Geppert et al., 1994; Li et al., 1994) . The expression of rabphilin 3A is reduced in an animal model of Huntington’s disease (Smith et al., 2005) . Rabphilin can be phosphorylated at Ser234 by both CAM kinase II and PKA and this phosphorylation has been suggested to regulate neuronal activity during development in a synapse-specific manner (Fykse et al., 1995; Foletti and Scheller, 2001) .
NCBI Gene ID
171039
Swiss Prot
P47709
Accession Number
P47709
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser234 of rabphilin 3A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Affinity Purified
Concentration
Batch dependent
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Rabphilin antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=50-236
Calculated Molecular Weight
82
Applications Notes
The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with mouse based on the fact that this species has 100% homology with the amino acid sequence used as antigen.
Symbol
Rph3a
NCBI Official Name
Rabphilin 3A
NCBI Organism
Rattus norvegicus
Background Reference 01
Foletti DL, Scheller RH (2001) Developmental regulation and specific brain distribution of phosphorabphilin. J Neurosci 21:5461-5472.
Background Reference 02
Fykse EM, Li C, Sudhof TC (1995) Phosphorylation of rabphilin-3A by Ca2+/calmodulin- and cAMP-dependent protein kinases in vitro. J Neurosci 15:2385-2395.
Background Reference 03
Geppert M, Bolshakov VY, Siegelbaum SA, Takei K, De Camilli P, Hammer RE, Südhof TC (1994) The role of Rab3A in neurotransmitter release. Nature (Lond) 369:493-497.
Tested Applications
WB, IHC
Protein ID
1350830
Physical Properties
Liquid
Curated Selection
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