Glycogen synthase (phospho Ser9) Antibody
Product Specifications
Background
Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that is involved in the regulation of many signaling pathways. To date, 2 isoforms have been identified: GSK3alpha and GSK3beta. Specifically, GSK3beta has been shown to play a key inhibitory role in both the insulin and Wnt signaling pathways (Papkoff and Aikawa 1998) . It has been suggested that Ser9 phosphorylation underlies the inhibition of GSK3beta by insulin (Sutherland et al., 1993) .
NCBI Gene ID
84027
Swiss Prot
P18266
Accession Number
P18266
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog, Zebrafish, Bovine, Chicken, Frog
Immunogen
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser9 of GSK3b.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Affinity Purified
Concentration
Batch dependent
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Glycogen synthase antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=50-228
Calculated Molecular Weight
46
Applications Notes
The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with human, mouse, chicken, bovine, canine, non-human primate, Zebra fish and Xenopus based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Symbol
Gsk3b
NCBI Official Name
Glycogen synthase kinase 3 beta
NCBI Organism
Rattus norvegicus
Background Reference 01
Sutherland C, Leighton IA, Cohen P (1993) Inactivation of glycogen synthase kinase 3 beta by phosphorylation: new kinase connections in insulin and growth factor signaling. Biochem J. Nov 15; 296 (Pt. 1) :15-9.
Background Reference 02
Papkoff J, Aikawa M (1998) WNT-1 and HGF regulate GSK3b activity and beta catenin signaling in mammary epithelial cells. Biochem Biophys Res Commun. Jun 29;247 (3) :851-8.
Tested Applications
WB
Protein ID
125374
Physical Properties
Liquid
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