GABAB Receptor (phospho Ser923) Antibody

Product Specifications

Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Phosphorylation enhances GABAB receptor effector coupling (Couve et al., 2004) . Phosphorylation of Ser923 is thought to be important in the regulation of GABAB receptor function.

NCBI Gene ID

81657

Swiss Prot

Q9Z0U4

Accession Number

Q9Z0U4

Host

Rabbit

Reactivity

Human, Mouse, Rat, Bovine

Immunogen

Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser923 of GABAB R1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific, Neuroscience

Purification

Affinity Purified

Concentration

Batch dependent

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

GABAB Receptor antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.

Calculated Molecular Weight

102

Applications Notes

The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, human, mouse and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

Symbol

Gabbr1

NCBI Official Name

Gamma-aminobutyric acid (GABA) B receptor 1

NCBI Organism

Rattus norvegicus

Background Reference 01

Couve A, Calver AR, Fairfax B, Moss SJ, Pangalos MN (2004) Unravelling the unusual signaling proerties of the GABA (B) receptor. Biochem. Pharmacol. Oct 12;68 (8) :1527-36.