GRASP Antibody
Product Specifications
Background
PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo (Scannevin and Huganir, 2000) . Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity (Ye et al., 2000) .
NCBI Gene ID
116493
Swiss Prot
Q9JHZ4
Accession Number
Q9JHZ4
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog, Bovine
Immunogen
Peptide corresponding to amino acid residues from the C-terminal region of rat GRASP, conjugated to keyhole limpet hemocyanin (KLH) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity Purified
Concentration
Batch dependent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
GRASP antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Calculated Molecular Weight
95
Applications Notes
The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, human and mouse based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Symbol
Gripap1
NCBI Official Name
GRIP1 associated protein 1
NCBI Organism
Rattus norvegicus
Background Reference 01
Scannevin RH, Huganir RL (2000) Postsynaptic organization and regulation of excitatory synapses. Nat Rev Neurosci 1:133-141.
Background Reference 02
Ye B, Liao DZ, Zhang XQ, Zhang PS, Dong HL, Huganir RL (2000) GRASP-1: A neuronal RasGEF associated with the AMPA receptor/GRIP complex. Neuron 26:603-617.
Tested Applications
WB
Protein ID
76363169
Physical Properties
Liquid
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS2037856-01 0.1 mL
FITC-Linked Polyclonal Antibody to Nerve Growth Factor (NGF)
Sign In for Pricing
View Details MBS2037856-02 0.2 mL
FITC-Linked Polyclonal Antibody to Nerve Growth Factor (NGF)
Sign In for Pricing
View Details