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DOPA Decarboxylase Antibody

Product Specifications

Background

DOPA decarboxylase (aromatic L-amino acid decarboxylase, AADC; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin (Waymire and Haycock, 2002; Berry et al., 1996; Haycock et al., 2003) . It is also involved in the biosynthesis of trace amines. DDC antibodies can therefore be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999) .

NCBI Gene ID

1644

Swiss Prot

P20711

Accession Number

P20711

Host

Rabbit

Reactivity

Human, Rat, Dog, Bovine, Goat, Sheep, Rabbit

Immunogen

Peptide from N-terminus region of human DOPA decarboxylase (DDC), conjugated to keyhole limpet hemocyanin (KLH) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Affinity Purified

Concentration

Batch dependent

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

DOPA Decarboxylase antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=50-202

Calculated Molecular Weight

55

Applications Notes

The antibody has been directly tested for reactivity in Western blots in bovine, canine, guinea pig, human, rabbit, rat and sheep tissues.

Symbol

DDC

NCBI Official Name

Dopa decarboxylase (aromatic L-amino acid decarboxylase)

NCBI Organism

Homo sapiens

Background Reference 01

Berry MD, Juorio AV, Li XM, Boulton AA (1996) Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme. Neurochem Res 21:1075-1087.

Background Reference 02

Haycock JW, Becker L, Ang L, Furukawa Y, Hornykiewicz O, Kish SJ (2003) Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum. J Neurochem 87:574-585.

Background Reference 03

Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001) Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24:561-567.

Tested Applications

WB

Protein ID

311033369

Physical Properties

Liquid

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