Synaptotagmin Antibody
Product Specifications
Background
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release (Littleton and Bellen 1995) . Recent studies indicate that synaptotagmin’s Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane fusion (Zhang et al., 2002) . It has recently been demonstrated that discrete residues within the c (2) b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size (Poskanzer et al., 2006) .
NCBI Gene ID
25716
Swiss Prot
P21707
Accession Number
P21707
Host
Rabbit
Reactivity
Human, Mouse, Rat, Bovine, Chicken
Immunogen
Synthetic peptide corresponding to amino acid residues within the synaptotagmin I protein.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Affinity Purified
Concentration
Batch dependent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Synaptotagmin antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=50-193
Calculated Molecular Weight
65
Symbol
Syt1
NCBI Official Name
Synaptotagmin I
NCBI Organism
Rattus norvegicus
Background Reference 01
Littleton JT, Bellen HJ (1995) Synaptotagmin controls and modulates synaptic vesicle fusion in a Ca (2+) dependent manner. Trends Neurosci. Apr;18 (4) :177-83.
Background Reference 02
Zhang X, Kim-Miller MJ, Fukuda M, Kowalchyk JA, Martin TF (2002) Ca2+ dependent synaptotagmin binding to SNAP25 is essential for Ca2+ triggered exocytosis. Neuron May 16;34 (4) :599-611.
Background Reference 03
Poskanzer KE, Fetter RD, Davis GW (2006) Discrete residues in the c (2) b domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Neuron Apr 6;50 (1) :49-62.
Tested Applications
WB
Protein ID
94730428
Physical Properties
Liquid
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