Synaptotagmin Antibody

Product Specifications

Background

Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release (Littleton and Bellen 1995) . Recent studies indicate that synaptotagmin’s Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane fusion (Zhang et al., 2002) . It has recently been demonstrated that discrete residues within the c (2) b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size (Poskanzer et al., 2006) .

NCBI Gene ID

25716

Swiss Prot

P21707

Accession Number

P21707

Host

Rabbit

Reactivity

Human, Mouse, Rat, Bovine, Chicken

Immunogen

Synthetic peptide corresponding to amino acid residues within the synaptotagmin I protein.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

Affinity Purified

Concentration

Batch dependent

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Synaptotagmin antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.

Calculated Molecular Weight

Symbol

Syt1

NCBI Official Name

Synaptotagmin I

NCBI Organism

Rattus norvegicus

Background Reference 01

Littleton JT, Bellen HJ (1995) Synaptotagmin controls and modulates synaptic vesicle fusion in a Ca (2+) dependent manner. Trends Neurosci. Apr;18 (4) :177-83.

Background Reference 02

Zhang X, Kim-Miller MJ, Fukuda M, Kowalchyk JA, Martin TF (2002) Ca2+ dependent synaptotagmin binding to SNAP25 is essential for Ca2+ triggered exocytosis. Neuron May 16;34 (4) :599-611.

Background Reference 03

Poskanzer KE, Fetter RD, Davis GW (2006) Discrete residues in the c (2) b domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Neuron Apr 6;50 (1) :49-62.