NSF Antibody
Product Specifications
Background
NSF (N-ethylmaleimide sensitive fusion protein) is a critical component of the SNARE (soluble NSF attachment protein receptors) protein complex that is involved in synaptic vesicle trafficking. Specifically, NSF has been found to be essential in membrane fusion. Furthermore, NSF has been recently demonstrated to bind other protein complexes such as AMPA receptor subunits (GluR2), GATE-16, LMA-1 and Rabs suggesting a more diverse role in the assembly of various protein complexes (Whiteheart et al., 2004) .
NCBI Gene ID
60355
Swiss Prot
Q9QUL6
Accession Number
Q9QUL6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide corresponding to amino acid residues from the C-terminal region of rat NSF, conjugated to keyhole limpet hemocyanin (KLH) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity Purified
Concentration
Batch dependent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NSF antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Calculated Molecular Weight
75
Applications Notes
The antibody has been directly tested for reactivity in rat tissue. It is anticipated that the antibody will also work with human and mouse based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Symbol
Nsf
NCBI Official Name
N-ethylmaleimide-sensitive factor
NCBI Organism
Rattus norvegicus
Background Reference 01
Schweizer FE, Dresbach T, DeBello WM, O’Connor V, Augustine G, Betz H (1998) Regulation of neurotransmitter release kinetics by NSF. Science 279 (5354) :1203-1206.
Background Reference 02
Matveeva EA, Whitehart SW, Vanaman T, Slevin J (2001) Phosphorylation of the N-ethylmaleimide sensitive factor is associated with depolarization-dependent neurotransmitter release from synaptosomes. J Biol.Chem. 276 (15) : 12174-12181.
Background Reference 03
Whitehart SW, Matveeva EA (2004) Multiple binding proteins suggest diverse functions for the N-ethylmaleimide sensitive factor. J Struct. Biol.146 (1-2) : 32-43.
Tested Applications
WB
Protein ID
81917630
Physical Properties
Liquid
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