Amyloid Precursor Protein Antibody
Product Specifications
Background
A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD) (Kamenetz et al., 2003) . The phosphorylation of APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003; Ando et al., 2001) .
NCBI Gene ID
54226
Swiss Prot
P08592
Accession Number
P08592
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Immunogen
Peptide corresponding to amino acid residues from the C-terminal region of rat APP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity Purified
Concentration
Batch dependent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Amyloid Precursor Protein antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=50-179
Calculated Molecular Weight
115
Applications Notes
The antibody has been directly tested for reactivity in rat tissue. It is anticipated that the antibody will also work with canine, chicken, human, mouse and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Symbol
App
NCBI Official Name
Amyloid beta (A4) precursor protein
NCBI Organism
Rattus norvegicus
Background Reference 01
Ando K, Iijima KI, Elliott JI, Kirino Y, Suzuki T (2001) Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid. J Biol Chem 276:40353-40361.
Background Reference 02
Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R (2003) APP processing and synaptic function. Neuron 37:925-937.
Background Reference 03
Liu F, Su Y, Li B, Zhou Y, Ryder J, Gonzalez-DeWhitt P, May PC, Ni B (2003) Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/cdk5 and p25/cdk5. FEBS Lett 547:193-196.
Tested Applications
WB
Protein ID
112930
Physical Properties
Liquid
Curated Selection
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