Retinoic Acid Receptor Antibody [336]
Product Specifications
Background
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005) . The Retinoid X receptors (RXRs) family (RXRalpha, beta and gamma) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors (RARs) . RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005) . RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005) .
NCBI Gene ID
5915
Swiss Prot
P10826
Accession Number
P10826
Host
Mouse
Reactivity
Human, Mouse, Rat, Dog, Goat
Immunogen
Peptide corresponding to amino acids from N-terminal region of human retinoic acid receptor, b-isotype.
Clonality
Monoclonal
Clone
336
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Protein G purified
Concentration
Batch dependent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Retinoic Acid Receptor antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=50-177
Calculated Molecular Weight
48
Fragment
IgG1
Applications Notes
The antibody has been directly tested for reactivity in Western blots in human tissues. It is anticipated that the antibody will also work with canine, guinea pig, mouse and rat tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Symbol
RARB
NCBI Official Name
Retinoic acid receptor, beta
NCBI Organism
Homo sapiens
Background Reference 01
Abu J, Batuwangala M, Herbert K, Symonds P (2005) Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer. Lancet Oncol 6:712-720.
Background Reference 02
Joshi S, Guleria R, Pan J, Dipette D, Singh US (2005) Retinoic acid receptors and tissue-trans-glutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells. Oncogene advance online publication 12 September 2005; doi: 10.1038/sj.onc.1209027.
Background Reference 03
Lane MA, Bailey SJ (2005) Role of retinoid signalling in the adult brain. Prog Neurobiol 75:275-293.
Tested Applications
WB
Protein ID
17380507
Physical Properties
Liquid
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
