Thyroid Hormone Receptor Antibody [2103]
Product Specifications
Background
Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000) . Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRalpha1, TRalpha2, TRbeta1 and TRbeta2. TRalpha1, TRbeta1 and TRbeta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005) .
NCBI Gene ID
7067
Swiss Prot
P10827
Accession Number
P10827
Host
Mouse
Reactivity
Human, Mouse, Rat, Dog
Immunogen
Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, a1/a2-isotype.
Clonality
Monoclonal
Clone
2103
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Protein G purified
Concentration
Batch dependent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Thyroid Hormone Receptor antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=50-170
Calculated Molecular Weight
50/58
Fragment
IgG1
Applications Notes
The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will react with canine, mouse and rat based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Symbol
THRA
NCBI Official Name
Thyroid hormone receptor, alpha
NCBI Organism
Homo sapiens
Background Reference 01
References: Ambrogini P, Cuppini R, Ferri P, Mancini C, Ciaroni S, Voci A, Gerdoni E, Gallo G (2005) Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat. Neuroendocrinology 81:244-253.
Background Reference 02
Chan S, Kilby MD (2000) Thyroid hormone and central nervous system development. J Endocrinol 165:1-8.
Background Reference 03
Constantinou C, Margarity M, Valcana T (2005) Region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors in adult rat brain. Mol Cell Biochem 278:93-100.
Tested Applications
WB
Protein ID
135705
Physical Properties
Liquid
Curated Selection
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