PSD-95 Antibody

Product Specifications

Background

PSD-95 is a very prominent component of the postsynaptic densities of synapses. It contains three PDZ domains which play key roles in its interactions with other proteins in the synapse. It has been proposed that these PDZ domains organize glutamate receptors and their associated signaling proteins and determine the size and strength of synapses (Kim and Sheng, 2004) . Recent work suggests that interaction of the NMDAR with PSD-95 via these PDZ domains can be regulated by phosphorylation (Chung et al., 2004) .

NCBI Gene ID

29495

Swiss Prot

P31016

Accession Number

P31016

Host

Rabbit

Reactivity

Human, Mouse, Rat, Bovine, Zebrafish

Immunogen

Peptide corresponding to amino acid residues from the N-terminal region of rat PSD-95, conjugated to keyhole limpet hemocyanin (KLH) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Affinity Purified

Concentration

Batch dependent

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PSD-95 antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.

Calculated Molecular Weight

Applications Notes

The antibody has been directly tested for reactivity in Western blots in rat and mouse tissues. It is anticipated that the antibody will also work with bovine, human, mouse, non-human primates and zebra fish tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

Symbol

Dlg4

NCBI Official Name

Discs, large homolog 4 (Drosophila)

NCBI Organism

Rattus norvegicus

Background Reference 01

Scannevin RH, Huganir RL (2000) Postsynaptic organization and regulation of excitatory synapses. Nat Rev Neurosci 1:133-141.

Background Reference 02

Ye B, Liao DZ, Zhang XQ, Zhang PS, Dong HL, Huganir RL (2000) GRASP-1: A neuronal RasGEF associated with the AMPA receptor/GRIP complex. Neuron 26:603-617.