YTH-IN-1
YTH-IN-1 (compound N-7) is a pan-YTH domain inhibitor with the IC50 values of 39 μM, 34 μM, 35 μM, 48 μM and 30 μM for human YTHYTHDF1, YTHYTHDF2, YTHYTHDF3, YTHYTHDC1, and YTHYTHDC2, respectively[1].
Product Specifications
CAS Number
[2189366-92-3]
UNSPSC
12352005
Target
Epigenetic Reader Domain; YTHDF
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yth-in-1.html
Purity
98.66
Solubility
DMSO : 2.5 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(C1)NCC21CCN(C3=C4N=CN(C5CC(CO)(CO)C5)C4=NC=N3)C2
Molecular Formula
C18H24N6O3
Molecular Weight
372.42
References & Citations
[1]Wang CH, et AL. Discovery of a new inhibitor for YTH domain-containing m6A RNA readers. RSC Chem Biol. 2024;5 (9) :914-923.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
YTHDC1; YTHDC2; YTHDF1; YTHDF2; YTHDF3
Available Sizes
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