PTRF 1 Antibody

Product Specifications

Background

Cavin 1-PTRF has been shown to be an essential component of caveolae. Cavin 1-PTRF appear to be recruited to membrane domains containing PS, cholesterol and oligomerized caveolins. Binding of Cavin 1-PTRF to these domains stabilizes the membrane curvature to produce the classic flask shape of caveolae. Disassembly of Cavin 1- PTRF releases caveolar components, including caveolins into the plasma membrane. Succinctly it appears that Cavin 1-PTRF regulates caveola structure and function.

NCBI Gene ID

284119

Swiss Prot

Q6NZI2

Accession Number

BAG60757

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic peptide corresponding to the C terminal region.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

Affinity Purified

Concentration

Batch dependent

Modification

None

Shipping Conditions

Dry Ice

Fragment

IgG

Applications Notes

ELISA, Western (immuno) blotting, Immunostaining (in testing)

Symbol

PTRF

NCBI Official Name

Polymerase I and transcript release factor

NCBI Organism

Homo sapiens

Background Reference 01

Hill MM, Bastiani M, Luetterforst R, Kirkham M, Kirkham A, Nixon SJ, Walser P, Abankwa D, Oorschot VM, Martin S, Hancock JF, Parton RG., PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function., Cell. 2008 Jan 11;132 (1) :23-4

Other Product Names

2310075E07Rik, AW546441, Cavin, MGC118550, Cavin 1, CAVIN1, CGL4, FKSG13, FLJ90031, OTTMUSP00000002049, polymerase I and transcript release factor, RNA polymerase I and transcript release factor, RP23-279L23.6, TTF I interacting 12, CAVIN, cavin-1