Huntington Protein Antibody
Product Specifications
Background
Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation of neuronal intracellular inclusions primarily in the striatum and cortex, leading to personality changes, motor impairment, and dementia. The Huntington’s disease protein is ~350 kDa in size and is localized in the brain.
NCBI Gene ID
3064
Swiss Prot
P42858
Accession Number
AAB38240
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to the N-terminus.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Affinity Purified
Concentration
Batch dependent
Modification
None
Shipping Conditions
Dry Ice
Fragment
IgG
Applications Notes
ELISA, Western (immuno) blotting, Immunostaining (in testing)
Symbol
HTT
NCBI Official Name
Huntingtin
NCBI Organism
Homo sapiens
Background Reference 01
Huntington's disease: from pathology and genetics to potential therapies. Imarisio S, Carmichael J, Korolchuk V, Chen CW, Saiki S, Rose C, Krishna G, Davies JE, Ttofi E, Underwood BR, Rubinsztein DC. Biochem J. 2008 Jun 1;412 (2) :191-209
Background Reference 02
Huntington disease models and human neuropathology: similarities and differences. Vonsattel JP. Acta Neuropathol. 2008 Jan;115 (1) :55-69
Background Reference 03
CHD proteins: a diverse family with strong ties. Hall JA, Georgel PT. Biochem Cell Biol. 2007 Aug;85 (4) :463-76
Background Reference 04
Characterization and localization of the Huntington disease gene product. André T. Hoogeveen*, Rob Willemsen, Nicolle Meyer, Karien E.de Roolj1, Raymund A.C. Roos2, Gert-Jan B.van Ommen1 and Hans Galjaard, Hum Mol Genet. 1993 Dec;2 (12) :2069-73
Other Product Names
HD, IT15, HD
Tested Applications
ELISA, WB, IHC
Protein ID
296434520
Physical Properties
Liquid
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