Huntington Protein Antibody

Product Specifications

Background

Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation of neuronal intracellular inclusions primarily in the striatum and cortex, leading to personality changes, motor impairment, and dementia. The Huntington’s disease protein is ~350 kDa in size and is localized in the brain.

NCBI Gene ID

3064

Swiss Prot

P42858

Accession Number

AAB38240

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to the N-terminus.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

Affinity Purified

Concentration

Batch dependent

Modification

None

Shipping Conditions

Dry Ice

Fragment

IgG

Applications Notes

ELISA, Western (immuno) blotting, Immunostaining (in testing)

Symbol

HTT

NCBI Official Name

Huntingtin

NCBI Organism

Homo sapiens

Background Reference 01

Huntington's disease: from pathology and genetics to potential therapies. Imarisio S, Carmichael J, Korolchuk V, Chen CW, Saiki S, Rose C, Krishna G, Davies JE, Ttofi E, Underwood BR, Rubinsztein DC. Biochem J. 2008 Jun 1;412 (2) :191-209

Background Reference 02

Huntington disease models and human neuropathology: similarities and differences. Vonsattel JP. Acta Neuropathol. 2008 Jan;115 (1) :55-69

Background Reference 03

CHD proteins: a diverse family with strong ties. Hall JA, Georgel PT. Biochem Cell Biol. 2007 Aug;85 (4) :463-76

Background Reference 04

Characterization and localization of the Huntington disease gene product. André T. Hoogeveen*, Rob Willemsen, Nicolle Meyer, Karien E.de Roolj1, Raymund A.C. Roos2, Gert-Jan B.van Ommen1 and Hans Galjaard, Hum Mol Genet. 1993 Dec;2 (12) :2069-73