Bloom Syndrome (phospho Ser527) Antibody
Product Specifications
Background
The Bloom syndrome gene product is a member of the RecQ helicase protein family. The protein contains 1417 amino acids; including one ATP binding site, one DEAH box, and two putative nuclear localization signals, as well as phosphorylation sites. BLS protein is known to associate and be phosphorylated by the ATR (ataxia telangiectasia, rad3+) protein, in response to genetic stress. The Bloom's syndrome gene product is thought to play a role in the etiology of two major human health problems, each of which is a very common complication of Bloom's syndrome, namely cancer and diabetes.
NCBI Gene ID
641
Swiss Prot
P54132
Accession Number
AAI15031
Host
Rabbit
Reactivity
Human, Mouse, Rat, Non-Human Primate
Immunogen
A synthetic peptide surrounding amino acid S527
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Affinity Purified
Concentration
Batch dependent
Modification
Phospho-Specific
Shipping Conditions
Dry Ice
Fragment
IgG
Applications Notes
ELISA, Western (immuno) blotting, Immunostaining (in testing)
Symbol
BLM
NCBI Official Name
Bloom syndrome, RecQ helicase-like
NCBI Organism
Homo sapiens
Background Reference 01
Nathan A. Ellis, Joanna Groden, , Tian-Zhang Ye, Joel Straughen, David J. Lennon, Susan Ciocci , Maria Proytcheva and James German The Bloom's syndrome gene product is homologous to RecQ helicases. Cell, (1994) Vol. 83, 655-668
Background Reference 02
Davies SL, North PS, Dart A, Lakin ND, Hickson ID., Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest. Mol Cell Biol. (2004) Feb;24 (3) :1279-91
Other Product Names
Bloom Syndrome Protein pS527 phospho specific, BS, RECQ2, RECQL2, RECQL3
Tested Applications
ELISA, WB, IHC
Protein ID
1705486
Physical Properties
Liquid
Frequently Asked Questions
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