Tropomyosin-1a (Ser 283) Antibody
Product Specifications
Background
Tropomyosin (Tpm-1) consists of a family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction..
NCBI Gene ID
7168
Swiss Prot
P09493
Accession Number
AAT68294
Host
Rabbit
Reactivity
Human, Mouse, Rat, Chicken, Non-Human Primate
Immunogen
A synthetic phosphopeptide corresponding to the region surrounding S283.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Affinity Purified
Concentration
Batch dependent
Modification
Phospho-Specific
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=39-877
Fragment
IgG
Applications Notes
ELISA, Western (immuno) blotting, Immunostaining (in testing)
Symbol
TPM1
NCBI Official Name
Tropomyosin 1 (alpha)
NCBI Organism
Homo sapiens
Background Reference 01
Quantitative comparison of sarcomeric phosphoproteomes of neonatal and adult rat. Yuan, C., Sheng, Q., Tang, H., Tixue, L., Zeng, R., and Solaro, R.J.. Am J Physiol Heart Circ Physiol.2008; 295: H647-H656.
Background Reference 02
P38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.Vahebi S, Ota A, Li M, Warren CM, de Tombe PP, Wang Y, Solaro RJ. Circ Res. 2007 Feb 16;100 (3) :408-15.
Other Product Names
Tropomyosin-1 (alpha), phospho serine 283, CMH3, TMSA, CMD1Y, LVNC9, C15orf13, HTM-alpha
Tested Applications
ELISA, WB, IHC
Protein ID
136092
Physical Properties
Lyophilized
Curated Selection
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