Tropomyosin-1a (Ser 283) Antibody

Tropomyosin (Tpm-1) consists of a family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction..

Quantitative comparison of sarcomeric phosphoproteomes of neonatal and adult rat. Yuan, C., Sheng, Q., Tang, H., Tixue, L., Zeng, R., and Solaro, R.J.. Am J Physiol Heart Circ Physiol.2008; 295: H647-H656.

P38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.Vahebi S, Ota A, Li M, Warren CM, de Tombe PP, Wang Y, Solaro RJ. Circ Res. 2007 Feb 16;100 (3) :408-15.